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. 2007 Oct 11;1784(1):76–93. doi: 10.1016/j.bbapap.2007.09.013

Fig. 3.

Fig. 3

Structures of complexes of JNK with ATP-competitive inhibitors or the JNK-inhibitory peptide derived from JIP. Crystal structures have been recorded in the PDB for JNK in the presence of a number of different ATP-competitive inhibitors. These include 1PMN: diaryl-imidazoles (Merck [5]), 2B1P: anilinoindazoles (Astra Zeneca [61]), 2GO1: pyrazoloquinolinones, 2GMX: aminopyridines and 2H96: pyridine carboxamides (Abbott [64], [65], [67]), 2EXC: anilino-bipyridines (Astra Zeneca [62]) and ZNO3: anilino-pyrimidines (Abbott [66]). The complex of JNK1 with SP600125 and the JNK inhibitory peptide derived from JIP1 is also indicated in 1UKI.