Table 4.
Studies reporting the results of surgical or post-mortem lung biopsies
|
Lung biopsy |
Invasive fungal infections | Mycobacterial infections | Need for steroids or chemotherapy | Comments | ||
|---|---|---|---|---|---|---|
| Surgical | Post-mortem | |||||
| White et al (2000)85 | 63 | 0 | 8 (13%) | 6 (9·5%) | 47 (75%) | Complication rate 13%; lower diagnostic yield in neutropenic patients and patients on IMV; higher diagnostic yield if focal infiltrates |
| Gossot et al (2001)86 | 21* | 0 | 0 | 0 | 8 of 29 (26%) | 0 of 9 biopsies of residual mass in patients with lymphoma |
| Dai et al (2001)87 | 7 | 0 | 1 (14%) | 0 | 3 (43%) | .. |
| Kim et al (2002)88 | 31 | 0 | 17 (55%) | 1 | 12 (39%) | All patients underwent lung biopsy for suspected invasive pulmonary aspergillosis |
| Sharma et al (2005)89 | 71 | 0 | 12 (17%) | 14 (20%) | 19 (27%) | All were adult bone marrow transplant recipients (39 allogeneic) |
| Zihlif et al (2005)90 | 62 | 0 | 14 (23%) | 0 | 31 (50%) | Complication rate 11%; lower diagnostic yield in patients on IMV |
| Gupta et al (2010)91 | 213 | 0 | 32 (15%) | 13 (6%) | 85 (40%) | Large or cavitary lesions or lung masses were more likely to yield a specific diagnosis |
| Sharma et al (2013)92 | 34† | 0 | 15 (44%) | NA | NA | .. |
| Gay et al (2013)93 | 11 | 10 | 0 | 5 (24%) | 5 (24%) | Only haematology patients |
| Uhlving et al (2015)94 | 44 | 13 (29·5%) | NA | 4 (9%) | Allogeneic bone marrow transplant recipients with biopsy-verified bronchiolitis obliterans | |
IMV=invasive mechanical ventilation. NA=not applicable.
*
8 CT-guided biopsies.
†
All CT-guided.