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. 2018 Jul 20;195:8–17. doi: 10.1016/j.clim.2018.07.009

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© 2018 Published by Elsevier Inc.

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Fig. 5 — Th1/Th2 and Th17/Treg imbalances are associated with SFTS patient outcomes.

(A) and (D): Correlation of Th1 with Th2 and Th17 with Tregs in the 42 SFTS patients (30 surviving and 12 deceased) at admission. Correlation analysis was performed via the non-parametric Spearman correlation test. (B) and (E): The Th1/Th2 and Th17/Treg ratios in the healthy controls (n = 11) and the surviving patients with SFTS in the acute phase (n = 30) and SFTS in the recovery phase (n = 30). (C) and (F): theTh1/Th2 and Th17/Treg ratios at admission in the surviving patients (n = 30) and the deceased patients (n = 12). (G) and (H): Dynamic changes in the Th1/Th2 and Th17/Treg ratios in the surviving patients (n = 30) and the deceased patients (n = 12). These parameters were monitored at the indicated time points for the entire hospital stay of the patients, and the dashed line represents the median of the uninfected controls. Data from (B), (C), (E), (F), (G) and (H) are shown as the median ± 95% CI. The statistical analysis was performed using the Mann-Whitney U test. The level of significance is indicated as follows: ns, not significant; *p < .05; **p < .01; ***p < .001; ****p < .0001;