Table 1.

Schedule of the studies (dpi = day post infectionem)

Study I	Group/no.	Sampling day	Parameters assessed (groups A–C)
Infection with 150,000 sporulated E. zuernii oocysts per calf (study day 0)	A/2	16 dpi (late prepatent period)	–clinical and parasitological parameters until pathological examination: see Study II
	B/2	21 dpi (patent period)	–pathologic-anatomical and histopathological findings in the mucosa
	C/2	26 dpi (late patent period/early postpatency)
Study II	Group/no.	Treatment	Parameters assessed (groups A–C)
Infection with 150,000 sporulated E. zuernii oocysts per calf (study day 0)	D/12	Toltrazuril (15 mg/kg, day 14 after infection)	–Clinical examination: daily
	E/11	-(sham dosing with water, day 14 after infection)	–Faecal consistency and oocyst excretion: on 0, 2, 5, 7, 9, 12 and 15–32 dpi