Table 2.
In vitro and in vivo models for Testing anti-viral agents against common viruses
| Name of virus | Disease | In vitromodel | In vivomodel |
|---|---|---|---|
|
HSV |
Herpes |
Plaque Assay (Vero, MRC-5, HFF, BHK, HEp-2) |
Mice, Rat, Rabbit Guinea pig |
|
Influenza |
Flu |
Plaque Assay, HA, HAI, RT-PCR, Real Time PCR (MDCK, A549 cell lines) |
Mice, Ferrets, Chicken |
|
Polio virus |
Paralysis, Aseptic meningitis |
Plaque Assay, RT-PCR (Hela cell) |
Mice, Rat |
|
HCV |
Liver cirrhosis |
RT-PCR, Real time, No cell line facility |
Chimpanzee |
| HBV | |||
|
Entero virus |
Diarrhoea |
RT-PCR, PAGE |
Mice, Rabbit |
|
RSV |
Common cold |
Plaque assay, MTT assay, RT-PCR Cell-ELISA, HEp-2 |
Mice, Rabbit |
|
Rabies |
Hydrophoba |
McCoy cells |
Mice |
| HIV | AIDS | Transgenic mice | |