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. 2013 May 23;16(4):485–492. doi: 10.1016/j.mib.2013.04.009

Figure 3.

Figure 3

RIG-I and IFITs recognize 5PPP RNA. (a) Several RNA viruses generate 5PPP RNAs, such as viral genomic RNAs. These RNAs are recognized by RIG-I that induces IFN production (green). IFNs then induce the expression of IFITs that bind and sequester 5PPP viral RNAs, preventing their translation, replication and/or packaging (red). Note that IFITs can also be induced directly by RIG-I/MAVS (dashed arrow) [43]. (b) The top row shows overall structures of RIG-I and IFIT5 in complex with 5PPP RNA; the bottom row zooms in on the 5PPP binding sites. The RIG-I structure is the RIG-I ΔCARD plus 5PPP RNA hairpin complex described in [33•] (PDB code 4AY2). IFIT5 is shown in complex with 5PPP-oligo-C [8••] (PDB code 4HOR). Amino acid residues contacting the 5PPP are shown in stick format and dashed lines indicate hydrogen-bonding interactions.