Fig. 2.
Interaction pattern between the inhibitor N3 and MHV-A59 Mpro.
(a) Stereo view of the interaction between N3 and the catalytic dyad. Residues and the N3 inhibitor are shown as sticks, and the covalent bond between N3 and C145 is shown by the magenta dashed line. The hydrogen bonds between the oxyanion loop and the P1 side chain are shown by the yellow dashed lines. The hydrogen bond inside the oxyanion loop is shown by the black dashed line. (b) Detailed view of N3 and the substrate-binding pocket, shown in stereo representation. The inhibitor is shown as green sticks, and the crucial residues of Mpro are shown as white sticks. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)