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. 2020 Apr 23;15:2859–2872. doi: 10.2147/IJN.S249751

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© 2020 Zhang et al.

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Effects of SHSs on the skin penetration of hucMSC-Exos in vitro and in vivo. (A) Penetration of fluorescent protein dye-labeled hucMSC-Exos (green) through porcine skin after 2-min massage by an electrical massager, 2-min application of a dermaroller, treatment of SHSs via 2-min massage by an electrical massager, and no treatment, respectively. The untreated skin was used as the blank to assess the autofluorescence of skin. (B) Deposition of dye-labeled hucMSC-Exos in each layer of skin. (C) Penetration of fluorescent protein dye-labeled hucMSC-Exos (green) through mouse skin treated with SHSs or untreated in vivo. All data were expressed as mean ± SD (n = 3). ***p < 0.001, versus the untreated exosome group.