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. 2020 Apr 23;12:2803–2827. doi: 10.2147/CMAR.S248094

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© 2020 Jin et al.

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Psoralen could reverse cisplatin resistance of GC cells via activating the miR196a-HOXB7-HER2 Pathway. (A and B) Using RT-qPCR, the miR-196a-5p relative expression levels after cultured with the three various concentrations of psoralen, compared to the negative control, in MGC803 cell line (A) and MGC803/DDP cell line (B) were analyzed. (C–F) The relative expression of HOXB7 (C), HER2 (D), Bcl-2 (E) and CCND1 (F) in MGC803 cell line and MGC803/DDP cell line following cultured with psoralen, as compared with the negative control, was analyzed by RT-qPCR. Each assay was conducted in triplicate. ****P < 0.0001, ***P < 0.001, **P < 0.01 and mean±SD were utilized to show the data.