Figure 11.

Psoralen combined with DDP improves the effect of chemotherapy and provides a clinical application for gastric cancer resistance to chemotherapy. (A) Cell activity was detected via MTT assay by dose-effect curve to investigate the ability of psoralen combined with DDP to affect the chemotherapy in MGC803 cells using the CompuSyn software. (B) Using MTT assay, the combination index plots of MGC803 cells following psoralen combined with DDP were calculated. (C) Cell activity was examined via MTT assay by dose-effect curve to investigate the ability of psoralen combined with DDP to affect the chemotherapy in MGC803/DDP cells using the CompuSyn software. (D) Using MTT assay, the combination index plots of MGC803/DDP cells following psoralen combined with DDP were calculated. (E and F) Cell activity (E) and the IC₅₀ values (F) were examined to evaluate the combined effects of DDP and 10μg/mL psoralen via MTT assay in MGC803 cells. (G and H) The cell viability (G) and the IC₅₀ values (H) of MGC803/DDP cell line following DDP alone and DDP combined with 10μg/mL psoralen were calculated by MTT assay. Each assay was conducted in triplicate. ****P < 0.0001 and mean±SD were utilized to show the data.