Table 1.

Physicochemical characteristics of the synthesized isatin derivatives.

Comp.	M. pt. (oC)	M. formula	M. wt.	Rf value	% Yield
Training set
1	246–248	C25H20N4O5S	488.12	0.72	85
2	88–90	C23H17N3O5S	447.76	0.70	80
3	252–254	C26H20N5O4S	483.10	0.68	72
4	268–270	C29H19N5O4S	498.53	0.64	76
5	213–215	C24H16N4O4S2	488.54	0.62	82
6	124–126	C27H21N5O4S	511.55	0.70	85
7	208–210	C26H19N5O5S	513.52	0.74	74
8	220–222	C26H18N4O4S	482.15	0.78	68
9	203–205	C25H17ClN4O5S	520.06	0.72	76
10	112–114	C26H18ClN5O4S	531.97	0.72	77
11	180–182	C27H20ClN5O6S	545.09	0.74	88
12	223–225	C26H18ClN5O5S	547.97	0.68	66
13	246–248	C25H17N4O5S	520.06	0.72	70
14	120–122	C23H17ClN3O5S	482.92	0.70	82
15	252–254	C25H16ClN5O4S	517.06	0.68	74
16	268–270	C29H18ClN5O4S	531.08	0.64	62
17	213–215	C24H16ClN4O4S2	523.99	0.62	76
18	124–126	C27H20ClN5O4S	545.09	0.70	82
19	208–210	C26H18ClN5O5S	547.97	0.74	70
20	220–222	C26H18ClN4O4S	517.96	0.78	87
21	108–110	C23H16ClN4O6S	476.08	0.72	58
22	112–114	C21H16N3O6S	438.43	0.64	64
23	100–102	C23H15N5O5S	473.46	0.68	78
24	195–197	C24H17N5O5S	487.49	0.72	84
25	148–150	C22H15N4O5S2	479.51	0.70	76
26	180–182	C25H19N5O5S	501.51	0.74	60
27	223–225	C24H17N5O6S	503.49	0.68	88
28	228–230	C24H16N4O5S	472.47	0.62	66
Test set
29	117–119	C23H17ClN3O5S	481.92	0.64	72
30	120–122	C25H17ClN5O4S	518.95	0.68	64
31	148–150	C24H16ClN4O4S2	523.99	0.70	82
32	228–230	C26H17ClN4O4S	516.96	0.62	70

TLC mobile phase: chloroform.