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. 2020 Apr 27;15(4):e0232047. doi: 10.1371/journal.pone.0232047

Fig 5. Both Nanos2 and Nanos3 are involved in the regulation of Dnd1-mediated teratoma susceptibility.

Fig 5

(A, B) Incidence of testicular teratomas in 129 male mice carrying the Dnd1-Δ allele and Nanos2-LacZ (A) or Nanos3-Cre (B) allele. The numbers of male mice examined were as follows: wild-type (N = 35), Nanos2+/LacZ (N = 57), Nanos2LacZ/LacZ (N = 17), Dnd1+/Δ; Nanos2+/LacZ (N = 49), and Dnd1+/Δ; Nanos2 LacZ/LacZ (N = 10) in (A), and wild-type (N = 45), Nanos3+/Cre (N = 62), Dnd1+/Δ; Nanos3+/Cre (N = 51), Nanos3Cre/Cre (N = 30), and Dnd1+/Δ; Nanos3Cre/Cre (N = 20) in (B). Blue, orange, and gray boxes in (A) and (B) indicate the percentages of cases where left, right, and both testes, respectively, were affected. (C, D) Comparison of the PGC number among wild-type, Nanos3+/Cre, and Nanos3Cre/Cre (C) or wild-type, Dnd1+/Δ, and Dnd1Δ/Δ (D) male embryos at E11.5.