Table 1.

Summary of viruses IFITM proteins have been tested against

Family	Virus	pH dependent	Restricts infectivity	Prevents cell–cell fusion	Pseudotyped virions (P) or live virus (L)	Restriction status	Reference
Enveloped
Orthomyxoviridae	Influenza A virus	✓✓	✓	✓	P L	M1–3	Brass et al. [11•], Smith et al. [16]
	Influenza B virus	✓✓	✓		L	M1–3	Everitt et al. [17•]
Flaviviridae	West Nile virus	✓	✓		P	M1–3	Brass et al. [11•]
	Dengue virus	✓✓	✓		P	M1–3	Brass et al. [11•]
	Hepatitis C virus	✓	✓/×		P L	M3 — no, M1 — yes	Brass et al. [11•], Wilkins et al. [24]
Rhabdoviridae	Vesicular stomatitis virus	✓	✓	✓	P L	M1–3	Weidner et al. [23]
	Rabies virus	✓✓	✓		P	M2–3	Smith et al. [16]
	Lagos Bat virus	✓✓	✓		P	M2–3	Smith et al. [16]
Filoviridae	Marburg virus	Δ	✓		P L	M1–3	Huang et al. [22•]
	Ebola virus	Δ	✓		P L	M1–3	Huang et al. [22•]
Coronaviridae	SARS coronavirus	Δ	✓		P L	M1–3	Huang et al. [22•]
Retroviridae	HIV-1	×	✓/×		P L	Mixed results	Brass et al. [11•], Lu et al. [26], Jia et al. [20]
	Moloney leukaemia virus	×	×		P L	No	Brass et al. [11•], Huang et al. [22•]
	Jaagsiekte sheep retrovirus	✓	✓	✓	P	M1 best	Li et al. [28•]
Arenaviridae	Lassa virus	✓	×		P	No	Brass et al. [11•]
	Machupo virus	✓	×		P	No	Brass et al. [11•]
	Lymphocytic choriomeningitis virus	✓	×		P	No	Brass et al. [11•]
Alphaviridae	Semliki Forest virus	✓	✓	✓	L	M2 and M3 best	Li et al. [28•]
Bunyaviridae	La Crosse virus	✓✓	✓		L	M1-3	Mudhasani et al. [30]
	Hantaan virus	✓✓	✓		L	M1-3	Mudhasani et al. [30]
	Andes virus	✓✓	✓		L	M1-3	Mudhasani et al. [30]
	Rift Valley fever virus	✓✓	✓		L-attenuated	M2 and M3	Mudhasani et al. [30]
	Crimean–Congo haemorrhagic fever virus	✓✓	×		L	No	Mudhasani et al. [30]
Non-enveloped
Reoviridae	Reovirus	✓✓	✓		L	M3	Anafu et al. [27]

✓, fuses at pH >6; ✓✓, fuses at pH <6; ×, does not require fusion; Δ, requires cathespin L in lysosome.