TABLE 2.
Treatment, outcomes, and reason for sacrifice in controls and desensitized animals
| Animal |
Desensitization |
Immunosuppression |
Survival (days) |
Complication/reason for sacrifice |
Serum creatinine at sacrifice |
|---|---|---|---|---|---|
| Bortezomib (n = 2) |
BTZ (3.5 mg/kg) |
NA |
NA |
Cardiopulmonary complications (death <48 h) |
NA |
| Bortezomib (n = 4) | BTZ (1.3 mg/m2) | NA | NA | Lost appetite | NA |
| Control (n = 6) | |||||
| Monkey 7a | none | Ind/TAC/MMF/Ster | 1 | Unknown, kidney failure | 10.2 |
| Monkey 6 | none | Ind/TAC/MMF/Ster | 1 | Kidney failure, hyperacute rejection | 5.28 |
| Monkey 8 | none | Ind/TAC/MMF/Ster | 7 | Kidney failure, rejection | 4.85 |
| Monkey 11 | none | Ind/TAC/MMF/Ster | 8 | Kidney failure, rejection | 7.64 |
| Monkey 9 | none | Ind/TAC/MMF/Ster | 27 | Kidney failure, rejection | 6.0 |
| Monkey 10 | none | Ind/TAC/MMF/Ster | 43 | Kidney failure, rejection | 7.81 |
| Monkey 5 | none | Ind/TAC/MMF/Ster | 44 | Kidney failure, rejection | 6.65 |
| Therapy (n = 5) | |||||
| Monkey 20a | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | 1 | Kidney failure, graft thrombosis | |
| Monkey 23 | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | 8 | Kidney failure, rejection | 8.6 |
| Monkey 21 | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | 16 | Urosepsis, monkey condition | 1.1 |
| Monkey 25 | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | 21 | Anemia, bone marrow depletionb | 0.9 |
| Monkey 22 | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | 41 | Retroperitoneal abscess | 0.55 |
| Monkey 24 | Bela/2C10/BTZ | Ind/TAC/MMF/Ster | >120 | No complication, end of study | 1.33 |
Ind, induction; TAC, tacrolimus, MMF; mycophenolate mofetil; Ster, steroids.
a
Monkey 7 and monkey 20 were excluded from posttransplant analysis.
b
Monkey 25 received three blood transfusions posttransplant for anemia.