Figure 1.

Schematic diagram of the development of designed peptide. After prospection, natural occurring AMPs are tested against pathogen microorganisms and putative candidates are selected based upon their biological activities. Peptide sequencing and structural characterization are key points to understand the structure-functional relationships of the AMP and to determine the surface interactions between the peptide and pathogen structures. Structural changed AMPs are chemically synthesized or recombinantly produced and their antimicrobial activities are evaluated based in optimized molecular interactions with the target pathogen.