Fig. 7.

Gefitinib (GFB) combined with cisplatin (cis) enhances the mitochondrial apoptosis in H358^R and A549^R cells. a Apoptosis ratio of cells incubated with cisplatin (cis), gefitinib (GFB), or a combination of two drugs for 48 h, was analyzed by flow cytometry. b Fluorescence microscope viewed mitochondrial membrane potential of cells after drugs treatment 48 h by JC-1 staining. c Expression of mitochondrial apoptosis-related protein in H358^R and A549^R cells when cisplatin (cis), gefitinib (GFB), or a combination of two drugs treatment 48 h, was examined by western blot (*P < 0.05, **P < 0.01)