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. 2020 Apr 1;31(8):825–832. doi: 10.1091/mbc.E19-07-0390

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© 2020 Madaan, Faure, et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 6: — Model for DBL-1/BMP pathway regulation by cuticle collagens. Green arrows represent forward DBL-1 signaling that regulates cuticle collagen expression and body size. DBL-1/BMP is expressed by and secreted from neurons of the ventral cord. It binds to receptors on the hypodermis (purple complex) and activates Smad signaling. Smad activation causes changes in gene expression leading to altered collagen composition of the cuticle. Yellow arrow depicts feedback signaling from the cuticle to a DBL-1/BMP–expressing cell.