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. 2020 Apr 1;31(8):782–792. doi: 10.1091/mbc.E19-09-0495

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© 2020 Feng et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 2: — p150 of dynactin promotes landing of DDB complexes. (A) Diagram of landing experiment in the presence of ATP. Initial landing of Qdot-labeled DDB complexes on microtubules can occur either through dynein or through dynactin p150. (B) Field of microtubules and attached DDB complexes for control (left) and in the presence of Ab_p150 (right). (C) Frequency of landing events in control (black, n = 10 microtubules in 50 s video length) and Ab_p150 (blue, n = 10 microtubules in 50 s video length). Error bars are SEM; ****, p < 0.001 by two-tailed t test. (D) Kymographs of DDB landing events, showing processive (P), diffusive (D), and stuck (S) events. (E) Frequency of processive, diffusive, and stuck landing events for control DDB (n = 10 microtubules in 50 s) and DDB in the presence of Ab_p150 (n = 10 microtubules in 50 s). Error bars are SEM; *, p < 0.05 and **, p < 0.01 by two-tailed t test.