Table 1:

Demographics of the leukodystrophy, overall PHIS and complex chronic condition (CCC) cohorts. Note: Due to missing data at the patient-, zip code- and hospital-levels, the total number of cases included in subsequent tables and analysis (including in the HGLM analyses) are fewer then reported here. The CCC cohort is only used in the sensitivity analysis.

	Leukodystrophy cohort	PHIS (non- leukodystrophy) cohort	PHIS CCC (non- leukodystrophy) cohort
N	501	1,245,391	511,351
Age at first admit in study period
Mean (min, max)	6.36 (0-18)	5.42 (0-18)	6.62 (0-18)
Inpatient days (per time in PHIS)
Mean (min, max)	0.045 (.0009-1.03)	0.186 (.0009-12.23)	0.340 (.0009-12.23)
Number of admits (per time in PHIS)
Mean (min, max)	0.113 (.03-2.0)	0.071 (.03-5)	0.03 (.082-.122)
Sex Number (%)
Male	304 (60.7)	665143 (53.4)	247148 (53.6)
Female	197 (39.3)	579908 (46.6)	237050 (46.4)
Race/Ethnicity Number (%)
White, non-Hispanic	241 (52.9)	532250 (48.1)	232477 (50.6)
Hispanic	110 (23.6)	262348 (23.2)	97741 (20.9)
Black, non-Hispanic	52 (11.4)	195202 (17.6)	82765 (18.0)
Asian, Non-Hispanic	10 (2.2)	39588 (3.6)	14488 (3.2)
Other race, Non-Hispanic	43 (10.8)	77793 (8.0)	32340 (7.9)
Payer Status Number (%)
Private Payer	168 (33.8)	502058 (41.1)	204964 (40.8)
Government Payer	293 (59.)	662388 (54.2)	274555 (54.6)
Other Payer	168 (33.8)	58124 (4.8)	23131 (4.6)
Leukodystrophy Type Number (%)
ALD	126 (25.1%)	0 (0)	0 (0)
MLD	124 (24.8)	0 (0)	0 (0)
Krabbe	62 (12.4)	0 (0)	0 (0)
Hurler	190 (37.9)	0 (0)	0 (0)