Fig. 4.

Simulated progression over 36 h (a through d) of a representative tumor lesion after exposure to a medium strength (${\lambda }_{\text{effect}}^N=280$) of a hypothetical “agent affecting macrophage polarization” (AAMP), simulating an immune therapeutic (as a fraction of the maximum in the vasculature) shifting the M1:M2 ratio to 3.0:1, in conjunction with a bolus injection of MSV-nab-PTX drug-loaded nanoparticles. Colors as in Fig. 3. Bar = 200 μm