Table 1.

Mutations introduced in ZNT5 and/or ZNT7 in HAP1 cells used in this study

Cells	Targeted region	Mutation
HAP–Z5-KOa	Exon 11	1-bp insertion in ZNT5
HAP–Z7-KOa	Exon 2	28-bp deletion in ZNT7
HAP–Z5Z7-DKOa	Exon 11 in ZNT5, exon 2 in ZNT7	2-bp deletion in ZNT5 and 28-bp deletion in ZNT7
HAP–Z7-KO(new)	Exon 2	165-bp insertion
HAP–Z5Z7-DKO(new)a	Exon 11 in ZNT5, exon 2 in ZNT7	32-bp deletion in ZNT5, 165-bp insertion in ZNT7

^a The detailed investigation is shown in Fig. S3.