Table 3.
Selected DEGs in Fatp2−/− mouse liver showing -fold change compared with WT
FC, -fold change; NS, not significant.
| Gene | Description | Males |
Females |
||
|---|---|---|---|---|---|
| FC | p | FC | p | ||
| Fatty acid transport and trafficking | |||||
| Cd36 | CD36/FAT | 5.9 | 7.18E−10 | 5.5 | 2.95E−23 |
| Fabp1 | Fatty acid–binding protein 1 | 1.6 | 7.11E−03 | NS | |
| Fatp1 | Fatty acid transport protein 1 | 3.8 | 1.38E−22 | 3.1 | 2.22E−06 |
| Acsl1 | Acyl-CoA synthetase long-chain 1 | 2.0 | 4.62E−09 | 2.1 | 2.28E−04 |
| Fatty acid oxidation | |||||
| Mitochondrial | |||||
| Cpt2 | Carnitine palmitoyltransferase 2 | 1.5 | 2.52E−03 | 2.0 | 1.42E−03 |
| Slc25A20 | Solute carrier family 25A20 | 1.8 | 8.63E−06 | NS | |
| AcadM | Acyl-CoA dehydrogenase medium chain | NS | 2.0 | 9.01E−04 | |
| AcadL | Acyl-CoA dehydrogenase long chain | NS | 1.9 | 6.42E−03 | |
| HadhA | Hydroxyacyl-CoA dehydrogenase A | 1.4 | 4.33E−02 | NS | |
| HadhB | Hydroxyacyl-CoA dehydrogenase B | NS | 1.8 | 4.46E−02 | |
| Acaa2 | Acetyl-CoA acyltransferase 2 | NS | 1.8 | 1.78E−02 | |
| Acot1 | Acyl-CoA thioesterase 1 | 8.6 | 9.68E−19 | 6.8 | 6.29E−30 |
| Acot3 | Acyl-CoA thioesterase 3 | 8.1 | 1.18E−03 | 2.1 | 4.16E−02 |
| Hmgcl | 3-Hydroxy-3-methylglutaryl-CoA lyase | 1.5 | 1.30E−02 | NS | |
| Ecl1 | Enoyl-CoA Δ-isomerase 1 | 1.8 | 2.26E−09 | 1.9 | 5.37E−06 |
| Ecl2 | Enoyl-CoA Δ-isomerase 2 | 2.0 | 7.05E−12 | NS | |
| Decr1 | 2,4-Dienoyl CoA reductase 1 | 1.7 | 6.07E−05 | 2.0 | 1.61E−03 |
| Etfdh | Electron-transferring flavoprotein | NS | 1.9 | 5.34E−03 | |
| Peroxisomal | |||||
| AbcD3 | ATP-binding cassette D3 | 1.8 | 2.10E−06 | 2.2 | 2.21E−05 |
| Acox1 | Acyl-CoA oxidase 1, palmitoyl | 2.3 | 9.75E−15 | 2.5 | 1.69E−06 |
| Acaa1A | Acetyl-CoA acyltransferase 1A | 1.6 | 3.34E−04 | 1.8 | 4.39E−02 |
| Acaa1B | Acetyl-CoA acyltransferase 1B | 3.5 | 1.42E−14 | 4.4 | 5.74E−18 |
| Ecl1 | Enoyl-CoA Δ-isomerase 1 | 1.8 | 2.26E−09 | 1.9 | 5.37E−06 |
| Ecl2 | Enoyl-CoA Δ-isomerase 2 | 2.0 | 7.05E−12 | NS | |
| Ehhadh | Enoyl-CoA, hydratase/dehydrogenase | 5.4 | 3.57E−40 | 6.1 | 1.75E−11 |
| Acot8 | Acyl-CoA thioesterase 8 | 1.8 | 1.14E−04 | NS | |
| Crat | Carnitine acetyltransferase | 3.3 | 1.32E−26 | 2.7 | 3.94E−07 |
| Decr2 | 2–4-Dienoyl-CoA reductase 2 | 1.6 | 6.82E-04 | NS | |
| Fatty acid synthesis | |||||
| Me1 | Malic enzyme 1, NADP+-dependent | 1.7 | 1.40E−02 | NS | |
| Scd1 | Stearoyl-CoA desaturase 1 | 1.9 | 3.77E−02 | NS | |
| Elovl5 | Fatty acyl-CoA elongase 5 | 1.4 | 3.69E−02 | NS | |
| Lipid body biogenesis | |||||
| Fitm1 | Fat storage-inducing transmembrane protein1 | 3.4 | 4.54E−05 | 6.8 | 5.91E−12 |
| Fitm2 | Fat storage–inducing transmembrane protein2 | 1.9 | 1.76E−06 | NS | |
| Plin2 | Perilipin 2 | 2.0 | 5.72E−09 | NS | |
| Plin5 | Perilipin 5 | 1.9 | 1.19E−06 | NS | |
| Mogat1 | Acyl-CoA:monoacylglycerol acyltransferase | 26.4 | 2.30E−06 | 111.2 | 1.02E−09 |
| Arachidonic acid metabolism | |||||
| Pla2 | Phospholipase A2 | 1.7 | 4.90E−05 | NS | |
| Cyp4A10 | Cytochrome P450, family 4a10 | 32.9 | 1.75E−52 | 11.6 | 2.52E−10 |
| Cyp4A14 | Cytochrome P450, family 4a14 | 407.3 | 2.47E−63 | 30.5 | 5.74E−18 |
| Cyp4A32 | Cytochrome P450, family 4a32 | 20.9 | 6.22E−08 | 5.9 | 4.45E−05 |
| Retinol metabolism | |||||
| Dhrs4 | Dehydrogenase/reductase member 4 | 1.6 | 5.13E−07 | 1.9 | 8.86E−06 |
| Aldh1A1 | Aldehyde dehydrogenase 1A1 | NS | 2.1 | 2.40E−03 | |
| Retsat | Retinol saturase, trans-retinol 13,14-reductase | 3.7 | 3.22E−15 | 7.7 | 1.45E−12 |
| Peroxisome biogenesis | |||||
| Pex11A | Peroxisomal biogenesis factor 11A | 2.3 | 3.88E−08 | 2.1 | 1.63E−03 |
| Pex16 | Peroxisomal biogenesis factor 16 | 1.5 | 8.37E−03 | NS | |
| PxmP4 | Peroxisomal membrane protein | 1.6 | 5.36E−04 | NS | |