Table 3.
Top 10 Differentially Expressed Messenger RNA Transcripts Up-Regulated in HCM Compared With Controls
| Gene | Official Full Name | Fold Change | q-Value | Gene Ontology Biological Process Term(s) | Gene Ontology Molecular Function Term(s) |
|---|---|---|---|---|---|
| ACE2 | Angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 | +3.53 | 1.30×10−23 | Angiotensin catabolic process in blood; regulation of inflammatory response; regulation of vasoconstriction | Peptidase activity; glycoprotein binding; zinc ion binding |
| SFRP1 | Secreted frizzled-related protein 1 | +3.32 | 5.93×10−21 | Regulation of cell growth; canonical Wnt receptor signaling pathway | Cysteine-type endopeptidase activity; Wnt-protein binding |
| RASL11B | RAS-like, family 11, member B | +3.30 | 3.44×10−22 | Small GTPase-mediated signal transduction | GTPase activity |
| CENPA | Centromere protein A | +3.25 | 3.37×10−16 | Nucleosome assembly | Chromatin binding; DNA binding; protein binding |
| APOA1 | Apolipoprotein A-I | +3.00 | 1.17×10−12 | Lipid metabolic process | Cholesterol transport activity |
| HS.576694 | Not available | +2.95 | 2.06×10−16 | Not available | Not available |
| SMOC2 | SPARC-related modular calcium binding 2 | +2.80 | 7.56×10−27 | Extracellular matrix organization | Calcium ion binding |
| PROS1 | Protein S (alpha) | +2.77 | 3.06×10−29 | Blood coagulation | Calcium ion binding |
| FRZB | Frizzled-related protein | +2.64 | 2.75×10−24 | Negative regulation of cell growth; negative regulation of Wnt receptor signaling pathway | Wnt-activated receptor activity; Wnt-protein binding |
| HSPA2 | Heat shock 70 kDa protein 2 | +2.62 | 1.07×10−16 | Positive regulation of cyclin-dependent protein kinase activity involved in G2/M | Adenosine triphosphate binding |
HCM = hypertrophic cardiomyopathy; GTPase = hydrolase enzyme that binds to the nucleotide guanosine triphosphate; RAS = rat sarcoma.