Table 4.
Top 10 Differentially Expressed mRNA Transcripts, Down-Regulated in HCM Compared With Controls
| Gene | Official Full Name | Fold Change q-Value | q-Value | Gene Ontology Biological Process Term(s) | Gene Ontology Molecular Function Term(s) |
|---|---|---|---|---|---|
| SERPINA3 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | −11.81 | 1.73×10−37 | Inflammatory response; regulation of proteolysis; regulation of lipid metabolic process | Peptidase inhibitor activity; DNA binding; protein binding |
| RASD1 | RAS, dexamethasone-induced 1 | −11.43 | 2.26×10−40 | Small GTPase-mediated signal transduction | GTP binding; GTPase activity |
| S100A9 | S100 calcium-binding protein A9 | −7.54 | 7.18×10−36 | Cell-cell signaling; leukocyte chemotaxis; actin cytoskeleton reorganization | Calcium ion binding; protein binding; signal transducer activity |
| S100A8 | S100 calcium-binding protein A8 | −6.27 | 1.23×10−30 | Inflammatory response; response to zinc ion; response to ethanol | Calcium ion binding; protein binding |
| MT1X | Metallothionein 1X | −5.18 | 1.02×10−30 | Response to metal ion | Zinc ion binding |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | −4.95 | 1.13×10−40 | Transcription from RNA polymerase II promoter | Protein dimerization activity; sequence-specific DNA binding |
| ZFP36 | Zinc finger protein 36, C3H type, homolog (mouse) | −4.72 | 2.07×10−40 | 3'-UTR-mediated mRNA stabilization | DNA binding; mRNA binding; protein binding; zinc ion binding |
| MT1M | Metallothionein 1M | −4.67 | 2.49×10−35 | Negative regulation of growth | Zinc ion binding |
| TUBA3D | Tubulin, alpha 3d | −4.61 | 1.75×10−39 | Microtubule-based movement | GTP binding; GTPase activity; structural molecule activity |
| TUBA3E | Tubulin, alpha 3e | −4.51 | 0.00 | Microtubule-based movement | GTP binding; GTPase activity; structural molecule activity |
HCM = hypertrophic cardiomyopathy; GTP = guanosine triphosphate; GTPase = hydrolase enzyme that binds to the nucleotide guanosine triphosphate; mRNA = messenger RNA; RAS = rat sarcoma; UTR = untranslated region.