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. 2020 Apr 28;38(28):4464–4475. doi: 10.1016/j.vaccine.2020.04.034

Table 2.

C7BL/6 maEBOV challenge study dosing regimen with PBS (buffer) controls. All challenges were done with Ebola virus M. musculus/COD/1976/Mayinga-CDC-808012 (maEBOV) delivered IP. Mice in Group 1 received no injections.

Dosing Table Vaccinated Animals versus PBS Controls 100, 1000, and 10,000 PFU maEBOV Challenge
Group N Active/ Control Formulation Route Challenge
1 4 Control N/A N/A N/A
2 10 Control PBS 400μl IP 100PFU maEBOV
3 10 Active 10 mg Adjuvanted Microspheres with NP44-52 400μl IP 100 PFU maEBOV
10 mg Adjuvanted Microspheres with VG-19
4 10 Control PBS 400μl IP 1,000PFU maEBOV
5 10 Active 10 mg Adjuvanted Microspheres with NP44-52 400μl IP 1,000 PFU maEBOV
10 mg Adjuvanted Microspheres with VG-19
6 10 Control PBS 400μl IP 10,000PFU maEBOV
7 10 Active 10 mg Adjuvanted Microspheres with NP44-52 400μl IP 10,000 PFU maEBOV
10 mg Adjuvanted Microspheres with VG-19