Table 4.
Summary of results from PRS-based analyses.
| ‘Target’ sample | ‘Base’ sample | |||||
|---|---|---|---|---|---|---|
| OCD | Type 2 Diabetes | HbA1c | Fasting insulin | Fasting glucose | 2 h Glucose | |
| PNC | ||||||
| Total OCS score | 4.72E-01 | 3.36E-01 | 7.64E-02 | 3.74E-01 | 4.16E-01 | 4.72E-01 |
| 0.04% | 0.28% | 1.00% | 0.19% | 0.10% | 0.02% | |
| Impairment | 2.61E-01 | 4.10E-01 | 2.28E-01 | 4.10E-01 | 4.10E-01 | 3.53E-01 |
| 0.51% | 0.11% | 0.58% | 0.11% | 0.12% | 0.22% | |
| Symmetry/counting/ordering | 3.53E-01 | 2.56E-01 | 4.10E-01 | 4.72E-01 | 2.80E-01 | 4.10E-01 |
| 0.23% | 0.53% | 0.11% | 0.04% | 0.39% | 0.11% | |
| Contamination/cleaning | 1.12E-01 | 3.53E-01 | 3.21E-01 | 4.47E-01 | 2.28E-01 | 2.71E-02 |
| 0.85% | 0.24% | 0.33% | 0.07% | 0.58% | 0.49% | |
| Aggressive taboo thoughts | 2.28E-01 | 5.95E-03 | 7.99E-02 | 4.66E-01 | 2.71E-01 | 2.28E-01 |
| 0.46% | 1.86% | 0.97% | 0.06% | 0.49% | 0.59% | |
| Guilty taboo thoughts | 2.52E-03 | 1.89E-0.1 | 4.03E-01 | 2.61E-01 | 3.21E-01 | 9.74E-02 |
| 2.28% | 0.68% | 0.15% | 0.52% | 0.33% | 0.90% | |
| Distress | 4.05E-01 | 4.72E-01 | 4.07E-01 | 2.80E-01 | 3.53E-01 | 3.53E-01 |
| 0.13% | 0.02% | 0.13% | 0.43% | 0.23% | 0.25% | |
| PGC | ||||||
| OCD | 2.80E-01 | 4.15E-01 | 7.67E-05 | 3.53E-01 | 4.75E-03 | |
| 0.03% | 0.01% | 0.26% | 0.02% | 0.14% | ||
| Spit for Science | ||||||
| Symmetry/counting/ordering TOCS | 2.42E-05 | 3.39E-01 | 2.71E-01 | 3.71E-01 | 2.47E-01 | 4.45E-01 |
| 0.49% | 0.03% | 0.04% | 0.02% | 0.04% | 0.01% | |
| Contamination/cleaning TOCS | 4.07E-03 | 1.59E-03 | 1.68E-01 | 4.37E-01 | 4.36E-01 | 3.76E-01 |
| 0.23% | 0.28% | 0.05% | 0.01% | 0.01% | 0.02% | |
Shown in this table are the Benjamini-Hochberg adjusted P-values at the best SNP P-value thresholds along with the variance explained for each of the ‘base’ and ‘target’ sample pairs from PRS analyses in PRSice. Significant findings are indicated in bold. PNC Philadelphia Neurodevelopmental Cohort, PGC Psychiatric Genomics Consortium, TOCS Toronto Obsessive-Compulsive Scale.