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. 2020 Apr 28;6:22. doi: 10.1038/s41421-020-0157-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP plots showing the distribution of chemokine receptors CCR7, CXCR3, CXCR6, CX3CR1, and CXCR5 matching with various T and NK cell subsets. b The heatmap indicating the expression of specific genes by chemokine receptors-defined NK & T cell clusters. Chemokine receptors expression correlates with the differentiation, effectorness and distribution patterns of CD8⁺ T and NK cell subsets. c The pool data by flow cytometry indicating the proportion of CCR7⁺ naive/CM T cells, CXCR3⁺ Tm, CXCR6⁺ Trm and CX3CR1⁺ Tc cells among CD8 T cells from peripheral blood (n = 13), liver perfusion (n = 5), and liver (n = 9), respectively. d The pool data by flow cytometry indicating the proportion of CXCR6⁺CX3CR1⁻ TrNK, CXCR6⁻CX3CR1⁺ NK cells, and CXCR6⁺CX3CR1⁺ double-positive (DP) and CXCR6⁻CX3CR1⁻ double-negative (DN) cells among CD3^-CD56⁺ total NK cells from peripheral blood (n = 13), liver perfusion (n = 5), and liver (n = 9), respectively. e Summary data indicating CD107a and IFN-γ production by CXCR6⁺ Trm from LP as compared to those from CXCR6⁻ T cells from LP (n = 11) and blood (n = 12) in responses to IL-12/IL-18 stimulations, respectively. f Summary data indicating CD107a and IFN-γ production by CXCR6⁺CD16⁻ TrNK cells from LP as compared to other NK cell subsets from LP (n = 11) and blood (n = 12) in responses to IL-12/IL-18 stimulations, respectively. **P < 0.01, ***P < 0.001, ****P < 0.0001, data are represented as mean ± SEM. PB peripheral blood, LP liver perfusion. g Immuno-histochemistry staining of CCR7, GZMK, and GZMB in the human liver by histological data from Protein Atlas, which represent naïve cells, tissue-resident cells and cNK cells, respectively. h The proportion of CXCR6 + cells among total T cells and NK cells from the liver biopsy in HC (n = 8), CHB patients (n = 12), and HBV-associated liver cirrhosis patients (n = 10). *P < 0.05, **P < 0.01, data are represented as mean ± SEM.