Table 1.

Correlation analysis between ZNF750 genotypes in 612 ESCC samples and clinicopathological variables.

Clinical, epidemiological or pathological feature	ZNF750_mut	Proportion	ZNF750_wt	Proportion	P value	ZNF750_mut
All cases	612	48	7.84%	564	92.16%
Age
<60	270	23	8.52%	247	91.48%
60–69	264	17	6.44%	247	93.56%	0.457
≥70	78	8	10.26%	70	89.74%
Sex
Male	439	39	8.88%	400	91.12%	0.137
Female	173	9	5.20%	164	94.80%
Tobacco use
No	262	17	6.49%	245	93.51%	0.293
Yes	350	31	8.86%	319	91.14%
Alcohol consumption
No	391	27	6.91%	364	93.09%	0.274
Yes	221	21	9.50%	200	90.50%
Tumor location
Upper thoracic	198	3	1.52%	195	98.48%
Middle thoracic	364	22	6.04%	342	93.96%	3.1427E-16
Lower thoracic	50	23	46.00%	27	54.00%
Histological grade
Grade 1	71	3	4.23%	68	95.77%	0.145
Grade 2	402	29	7.21%	373	92.79%	0.145
Grade 3	139	16	11.51%	123	88.49%
Pathologic Stage
I&II	374	16	4.28%	358	95.72%	8E-05
III&IV	238	32	13.45%	206	86.55%
Pathologic T Stage
T1	47	4	8.51%	43	91.49%
T2	213	13	6.10%	200	93.90%	0.003
T3	341	26	7.62%	315	92.38%
T4	11	5	45.45%	6	54.55%
Pathologic N Stage
N0	355	16	4.51%	339	95.49%
N1	147	15	10.20%	132	89.80%	0.001
N2	79	13	16.46%	66	83.54%
N3	31	4	12.90%	27	87.10%
Lymphatic metastasis
Yes	257	33	12.84%	224	87.16%	0.0001
No	355	15	4.23%	340	95.77%
Prognosis (Log-rank Mantel-Cox test)
Dead	263	29	11.03%	234	88.97%
Survival	324	17	5.25%	307	94.75%	0.026
Missing	25	2	8.00%	23	92.00%