Table 5.

Comparison of the various computed tomography techniques used to evaluate myocardial ischemia

	Advantages	Disadvantages
Coronary CTA	Visualization of coronary artery stenosis and plaque morphology	Unassessable segments (artifact, calcification)
	Widely available in clinical practice	Low PPV for detecting myocardial ischemia
CT-FFR	CTA anatomy- and CFD-based functional assessment	Depends on image quality of coronary CTA
	No scan additional to coronary CTA	Appropriate patient selection (image-related, patient-related factors influencing CT-FFR calculation)
	High diagnostic performance	Remote service (time-consuming)
	Effective modification to coronary CTA based decision-making	On-site analysis (requiring a learning period, objectivity)
		Less information on the stenosis-related territory
CTP	High spatial resolution	Radiation exposure and contrast dose additional to coronary CTA
	Real-time stress myocardial perfusion imaging	Risk of side effects from the vasodilator agent
	Visualization of myocardial ischemia (area and transmural extent)	Long examination time (30–60 min)
	Quantification (CT-MBF using dynamic CTP)
	Incremental value to coronary CTA

CFD computational flow dynamics, CTA computed tomography angiography, CT-FFR computed tomography-derived fractional flow reserve, CT-MBF computed tomography derived myocardial blood flow, CTP computed tomography perfusion, PCI percutaneous coronary intervention