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. 2020 Apr 21;11:272. doi: 10.3389/fpsyt.2020.00272

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Copyright © 2020 Bi, Zhan, Zhou and Sui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ZBPYR on cognitive impairment in the Morris water maze (MWM) test. The escape latencies of the animals were analyzed in the training trials (A). Performance in the probe test was analyzed, including time searching for the original platform location (B) and number of crossings over the original platform location (C). Escape latency in the visible platform version of the MWM test was also analyzed (D). Bars represent the mean ± SEM of 6 rats per group. ^** P < 0.01, ^**** P < 0.0001, PSD group vs. ZDF group; ^# P < 0.05, ^## P < 0.01, PDZ group vs. PSD group.