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. 2020 Apr 21;11:272. doi: 10.3389/fpsyt.2020.00272

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Copyright © 2020 Bi, Zhan, Zhou and Sui

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ZBPYR on generation and deposition of β-amyloid in the medial prefrontal cortex (mPFC) of ZDF rats. Levels of soluble and insoluble Aβ40 and Aβ42 in the mPFC of each group were measured using enzyme-linked immunosorbent assay (A–D). Protein expression of APP in the mPFC of each group were detected by western blotting (E, F). Bars represent the mean ± SEM. ****P < 0.0001, PSD group vs. ZDF group; ^## P < 0.01, ^#### P < 0.0001, PDZ group vs. PSD group.