Table 2.
Summary of clinical data in DM1 patients divided by severity of muscular disability.
| MIRS 1-3 | MIRS 4-5 | p-value | RR of MIRS 4-5/1-3 (95%CI) | |||
|---|---|---|---|---|---|---|
| % | Mean (SD) | % | Mean (SD) | |||
| Age (years) | 31.8 (11.4) | 40.2 (10.7) | <0.05 | |||
| Onset age (years) | 27.2 (11.8) | 27.2 (12.2) | NS | |||
| Disease duration (years) | 4.0 (2.0-6.0)a | 12.0 (8.0-20.0)a | <0.05 | |||
| Sex (male) | 67.9 | 57.9 | NS | 0.65 (0.274-1.541) | ||
| Creatine kinase (U/L) | 288.9 (135.8) | 331.7 (231.0) | NS | |||
| Increased level of CK | 75.6 | 69.4 | NS | 0.73 (0.268-2.004) | ||
| Cataract | 35.7 | 57.7 | NS | 2.46 (0.901-6.684) | ||
| Frontal balding | 32.1 | 52.6 | 0.49 | 2.35 (0.997-5.556) | ||
| Cardiac abnormalities | 25.5 | 48.5 | <0.05 | 2.75 (1.087-6.964) | ||
| Conduction disorders | 15.7 | 36.4 | <0.05 | 3.07 (1.090-8.652) | ||
| Rhythm disorders | 9.8 | 12.1 | NS | 1.27 (0.315-5.118) | ||
| Insulin insensitivity | 12.8 | 14.3 | NS | 1.14 (0.292-4.445) | ||
| Thyroid dysfunction | 7.5 | 25 | NS | 4.11 (0.921-18.351) | ||
| Hypogonadism | 33.3 | 53.6 | NS | 2.31 (0.888-5.996) | ||
a
M (IQR), NS, not significant.