Table 5.
Neuroanatomical associations of altered time awareness in the patient cohort.
| Region | Side | Cluster (voxels) | Peak (mm) | T score | PFWE | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Middle temporal gyrus/superior temporal sulcus | L | 118 | −50 | −3 | −26 | 3.95 | 0.038 |
| Hippocampus | L | 31 | −22 | −33 | −4 | 3.74 | 0.019 |
| Posterior cingulate | L | 184 | −2 | −24 | 33 | 4.52 | 0.015 |
| Superior parietal lobule | L | 75 | −32 | −57 | 51 | 4.23 | 0.038 |
The table presents the locations of regional gray matter positively correlated with tendency to re-live past events (the only significant association of altered time awareness identified) over the combined patient cohort, based on voxel-based morphometry (see text and Tables 2, 3 for further details). Coordinates of local maxima are in standard MNI space. P-values were all significant (p < 0.05) after family-wise error (FWE) correction for multiple voxel-wise comparisons within pre-specified anatomical regions of interest (see text).