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. 2020 Apr 21;11:250. doi: 10.3389/fneur.2020.00250

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Copyright © 2020 Yang, Huang, Luo, Li, Qin, Ma, Shao, Xu, Zhang, Xu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar graph of group differences on the whole-brain network properties. Data were presented as mean ± SD. (A,C) No significant difference in network density and clustering coefficient among the three groups (ANCOVA, P > 0.05). (B,E) WMH-no-CI and WMH-CI groups displayed lower network strength and global efficiency than HC group (ANCOVA, P < 0.001; Bonferroni-corrected, P < 0.05/3). (D) WMH-no-CI and WMH-CI groups displayed higher path length than HC group (ANCOVA, P < 0.001; Bonferroni-corrected, P < 0.05/3). (F) WMH-no-CI group displayed lower local efficiency than HC group (ANCOVA, P < 0.05; Bonferroni-corrected, P < 0.05/3). Cp, clustering coefficient; CI, cognitive impairment; Eg, global efficiency; Eloc, local efficiency; HC, healthy controls; Lp, path length; WMH, white matter hyperintensity.