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. 2020 Apr 21;10:549. doi: 10.3389/fonc.2020.00549

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Copyright © 2020 Morillon, Smalley Rumfield, Pellom, Sabzevari, Roller, Horn, Jochems, Palena, Greiner and Schlom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct transcriptional changes within the TME following bintrafusp alfa treatment. (A,B) Heatmap RNA expression profile from a NanoString pan-cancer immune profiling panel assayed on enriched CD45⁺ cells from tumors of control and bintrafusp alfa-treated mice bearing HTB-1 tumors at day 21 post-initiation of bintrafusp alfa treatment (A) or SiHa tumors at day 22 post-initiation of bintrafusp alfa treatment (B) (fold change >1.5, ANOVA p < 0.1). (C) Ingenuity pathway analysis of HTB-1 and SiHa RNA expression profiles describing those pathways most altered with bintrafusp alfa treatment; (*) denotes pathways altered in both HTB-1 and SiHa tumors; (X) denotes pathways altered in SiHa tumors only. (D) String analysis of those genes altered in the top 5 pathways identified by Ingenuity Pathway Analysis. Red nodes denote those genes/pathways identified post-bintrafusp alfa treatment in both HTB-1 and SiHa tumors; blue nodes denote those genes/pathways identified post-bintrafusp alfa treatment in SiHa tumors only.