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. 2020 Apr 21;10:549. doi: 10.3389/fonc.2020.00549

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Copyright © 2020 Morillon, Smalley Rumfield, Pellom, Sabzevari, Roller, Horn, Jochems, Palena, Greiner and Schlom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analyses of peripheral and intratumoral CD8⁺ T-cell PD1 expression following bintrafusp alfa administration. (A) Association between PD1 expression in splenic (A) or intratumoral (B) CD8⁺ T cells vs. tumor weight at day 21 post-initiation of bintrafusp alfa treatment in bintrafusp alfa-treated PBMC humanized mice. (C) Splenic or (D) tumor CD8⁺ PD1 expression in animals responding to bintrafusp alfa (tumor weight <263 mg) vs. those not responding (tumor weight >263 mg) in HTB-1 humanized mice (***p < 0.0001, student's t-test).