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. 2020 Apr 21;12:15. doi: 10.3389/fnsyn.2020.00015

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Copyright © 2020 Bouquier, Girard, Aparicio Arias, Fagni, Bertaso and Perroy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental protocol of ACPPs injection in a mouse model of epileptogenesis. (A) Scheme of kainic acid (KA) and ACPPs injections in hippocampal hemispheres. (B) Scheme of hippocampal structure and lamination. CA, cornu ammonis; DG, dentate gyrus; H, hilus; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum; SLM, stratum lacunosum-moleculare; SM, stratum moleculare; SG, stratum granulosum. (C) Experimental procedure: timeline of injections. (D) Hoechst labeled nuclei showing progressive dentate gyrus cell dispersion in KA injected hippocampus, characteristic of epileptogenesis (scale bar: 1 mm). Corresponding EEG recordings representative of the different severity scores are shown on the right. Score 0: normal activity; score 1: low-voltage background activity; score 3: short discharges; score 5: recurrent seizures.