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. 2020 Apr 21;14:267. doi: 10.3389/fnins.2020.00267

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Copyright © 2020 Song and Long.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The networks of ferroptosis-related proteins targeted by nuclear factor E2 related factor 2 (Nrf2/NFE2L2) (Protein interaction network from STRING database: https://string-db.org/cgi/input.pl and edited by cytospace3.7.1 software). Nrf2 can regulate ferroptosis directly through GPX4 synthesis-related enzyme [glucose-6-phosphate dehydrogenase (G6PD), glutathione (GSH) reductase (GSR), GSH peroxidase 4 (GPX4), glutamate-cysteine ligase modifier subunit (GCLM), 12-channel transmembrane protein transporter vector family 7 member 11 (SLC7A11), glutamate-cysteine ligase catalytic subunit (GCLC), thioredoxin reductase 1 (TXNRD1)] or through the peroxisome proliferator-activated receptor gamma (PPARγ) pathway. Nrf2 can indirectly regulate intracellular iron concentration via Nrf2-heme oxygenase 1 (HMOX1)-iron regulatory-related protein axis [biliverdin reductase A/B (BLVRA/B), ferritin heavy chain 1 (FTH1), transferrin receptor 1 (TFRC), recombinant ferrochelatase (FECH), ferroportin (FPN1/SLC40A11)] to regulate ferroptosis.