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. 2020 Apr 21;10:485. doi: 10.3389/fonc.2020.00485

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Copyright © 2020 Liu, Wang, Zhang, Jin, Qu, Jin, Zheng, Sun, Wu, Wang, Liu, Zhang, Meng, Wang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The HDAC10 expression in NSCLC tissues is higher than that in normal lung tissues. (A) Tumor tissue and para-cancer lung tissue were stained with HDAC10 antibody. Using both the IHC staining intensity and the proportion of cells stained, the IHC score was determined by a semi-quantitative method. The expression level was further classified into low expression (≤1), moderate expression (1.5-6) and high positive expression (≥7.5) for HDAC10. A representative image of high-, medium- and low-level expression of HDAC10 in 180 patients with NSCLC receiving pulmonectomy (a, b, c), and HDAC10 expression in its corresponding para-cancer tissues (d) were shown. (B) Oncomine database for HDAC10 expression in NSCLC tissue (n = 226) and normal lung tissue (n = 20).