TABLE 2.
Main and interaction effects of rs11146020 and rs3813296 on causality connectivity in frontal-striatum-thalamus pathway.
| rs11146020 main effect on causality connectivity in frontal- striatum- thalamus pathway | ||||
| GG vs. CG | ||||
| Causality connectivity | Connection strength |
F(1) value | P value | |
| GG | CG | |||
| L.dLPFCR.dLPFC | −0.028 ± 0.022 | 0.047 ± 0.027 | 8.29 | 0.006 |
| R.dLPFCL.dLPFC | 0.02 ± 0.024 | −0.085 ± 0.03 | 7.539 | 0.009 |
|
rs3813296 main effect on causality connectivity in frontal- striatum- thalamus pathway | ||||
|
GT vs. TT | ||||
| Causality connectivity |
Connection strength |
F(1) value | P value | |
| TT | GT | |||
| L.dLPFCR.Caudate | 0.056 ± 0.016 | 0.015 ± 0.015 | 7.535 | 0.009 |
| R.dLPFCR.Thalamus | 0.008 ± 0.012 | 0.026 ± 0.013 | 9.147 | 0.003 |
|
rs11146020*rs3813296 inteaction effect on causality connectivity in frontal- striatum- thalamus pathway | ||||
|
CG/GT vs. GG/GT | ||||
| Causality connectivity |
Connection strength |
F(1) value | P value | |
| GG/GT | CG/GT | |||
| L.PallidumL.dLPFC | −0.032 ± 0.06 | 0.116 ± 0.071 | 8.691 | 0.0043 |
| L.PallidumR.dLPFC | −0.078 ± 0.051 | 0.096 ± 0.06 | 9.487 | 0.0024 |
|
CG/TT vs. GG/GT | ||||
| Causality connectivity |
Connection strength |
F(1) value | P value | |
| GG/GT | CG/TT | |||
| R.PallidumR.dLPFC | −0.08 ± 0.057 | 0.169 ± 0.068 | 9.366 | 0.0029 |
| R.PallidumR.Caudate | 0.036 ± 0.026 | 0.134 ± 0.025 | 8.662 | 0.0044 |
Data are given as mean ± standard deviation; P and corresponding F values were obtained from multivariable GLM analysis by applying the Mann–Whitney U test and FDR correction (P < 0.01). GLM, general linear model; FDR, false discovery rate; dLPFC, dorsolateral prefrontal cortex.