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. 2020 Apr 21;11:713. doi: 10.3389/fimmu.2020.00713

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Copyright © 2020 Pollara, Edwards, Jha, Lam, Liu, Diedrich, Nordstrom, Huffman, Pickeral, Denny, Permar and Ferrari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cord blood mononuclear cell (CBMC) CD8⁺ T cells subset distribution (left panels) and activation state (right panels) after (A) overnight rest, (B) 3 days of T cell receptor stimulation (anti-CD3, anti-CD28, and IL-2), or (C) 3 day transition from activated cells back to the resting state. Representative example shown. Similar levels of DART molecule-redirected killing of autologous HIV-1 4403bmC5-infeced CD4⁺ T cells were observed in assays performed with (D) CD8⁺ T cell effectors after overnight rest, and (E) as they returned back to a resting state following 3 days of T cell receptor stimulation. (D,E) represent data from 24 h killing assays with a CD8⁺ effector to HIV-1 4403bmC5-infected autologous CD4⁺ target cell ratio of 30:1, performed using three different CBMC donors, each represented by individual lines.