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Tumor hypoxia and perineural invasion (PNI). (A,B) Differences in hypoxia scores (signature authors are shown) in ACRG between PNI-positive and PNI-negative GC: A clustered heat map (A) and direct comparisons (B). (C) Typical micrographs of ERO1A-negative and ERO1A-positive tumors, at 400× magnification. (D) Different positive rates of ERO1A between PNI-positive and PNI-negative GC. ACRG, Asian Cancer Research Group; GC: gastric cancer.
