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. 2020 Apr 21;10:530. doi: 10.3389/fonc.2020.00530

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Copyright © 2020 Tao, Zhu, Zhao, Li, Shu, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling scores, thymidylate synthetase (TS, TYMS) expression, and perineural invasion (PNI). (A) A clustered heat map for signaling scores and TYMS expression in ACRG. (B) The correlations between hypoxia scores (signature authors are shown) and signaling scores (Spearman correlation coefficients were shown and a fork mark indicated non-significant correlation). (C) Differences in signaling scores and TYMS expression between PNI-positive and PNI-negative GC. (D) Typical micrographs of TS-negative and TS-positive tumors, at 400× magnification. (E) Different positive rates of TS between PNI-positive and PNI-negative GC. GC, gastric cancer; ACRG, Asian Cancer Research Group.