Figure 4.

Spatial learning and memory. The Morris water maze test was performed at 11 weeks of age. We measured swimming duration (A,G), swimming distance (C,I) until mice reached the hidden platform, and swimming speed (E,K) for five consecutive days. We presented the average of the 5-day sessions for swimming duration (B,H), swimming distance (D,J), and swimming speed (F,L). *P < 0.05 and **P < 0.01. The results in males (A–F) and females (G–L) are shown. In male groups: 2N-Regular (n = 20), 2N-Cilostazol (n = 15), Ts65Dn-Regular (n = 8), Ts65Dn-Cilostazol (n = 10). In female groups: 2N-Regular (n = 9), 2N-Cilostazol (n = 18), Ts65Dn-Regular (n = 11), Ts65Dn-Cilostazol (n = 10). Mean ± SEM.