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. 2020 Mar;8(6):329. doi: 10.21037/atm.2020.02.145

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TET2 expression during tumorigenesis in 4NQO-induced HNSCC animal model. Immunohistochemical staining of TET2 in samples from diverse stages in 4NQO-induced animal model. Images in the upper panel (A,C,E,G) are representative staining of TET2 in normal, epithelial with hyperplasia, epithelial with severe dysplasia/carcinoma in situ and squamous cell carcinoma, respectively. Images in the lower panel (B,D,F,H) are magnified from the black box area in the A, C, E, G images in the upper panel, respectively. The number of animals in each stage during 4NQO-induced HNSCC model was 10. Scale bar: 100 µm. TET2, tet methylcytosine dioxygenase 2; 4NQO, 4-nitroquinoline-1-oxide; HNSCC, head neck squamous cell carcinoma.