Table 1. The associations between TET2 expression and multiple clinicopathological parameters in HNSCC samples.

Clinicopathological parameters	Cases	TET2		P value
		Low*	High
Gender	101	61	40
Male	52	31	21	>0.9999
Female	49	30	19
Age
≤60	40	22	18	0.4098
>60	61	39	22
Smoking
No	73	42	31	0.3732
Yes	28	19	9
Alcohol use
No	79	48	31	>0.9999
Yes	22	13	9
Tumor size
T1–T2	68	38	30	0.0278#
T3–T4	43	33	10
Pathological grade
I	59	35	24	0.8386
II–III	42	26	16
Cervical node metastasis
N0	66	42	24	0.3976
N+	35	19	16
Clinical stage
I–II	52	26	26	0.0413#
III–IV	49	35	14

*Both of patients with low and negative TET2 staining are stratified into low TET2 category for simplicity. ^#indicate statistical significance with P values less than 0.05. TET2, tet methylcytosine dioxygenase 2; HNSCC, head neck squamous cell carcinoma.