Table 3. Univariate and multivariate survival analyses (proportional hazards method) for patients with primary HNSCC.

Variable	Univariate survival analysis				Multivariate survival analysis
	Hazard ratio	95% CI	P value		Hazard ratio	95% CI	P value
Gender (male, female)	1.133	0.622–2.062	0.683				N/A
Smoking (no, yes)	0.922	0.538–1.830	0.980				N/A
Alcohol use (no, yes)	0.920	0.472–1.793	0.807				N/A
Age (>60, ≤60)	1.333	0.671–2.646	0.412		0.961	0.517–1.787	0.901
Tumor size (T3–T4, T1–T2)	1.555	0.847–2.853	0.154		1.197	0.574–2.497	0.632
Pathological grade (II–III, I)	1.182	0.667–2.094	0.567		1.164	0.601–2.220	0.645
Cervical nodal metastasis (N+, N0)	1.096	1.590–2.035	0.773		0.856	0.283–2.588	0.783
Clinical stage (III–IV, I–II)	1.658	0.903–3.044	0.103		0.751	0.375–1.579	0.450
TET2 expression (high, low)	0.514	0.268–0.987	0.045#		0.509	0.265–0.982	0.044#

^#Indicate statistical significance with P values less than 0.05. HNSCC, head neck squamous cell carcinoma; TET2, tet methylcytosine dioxygenase 2.