Table 2. Univariate and multivariate analysis of USP2 mRNA level and patient overall survival.

Variable	Univariate analysis				Multivariate analysis
	HRa	95% CIb	P		HR	95% CI	P
Overall survival (n=524)
Age (years)
≥60 (n=282)
<60 (n=242)	1.797	1.312–2.460	0.000		1.537	1.112–2.125	0.009
Gender
Male (n=339)
Female (n=185)	0.944	0.693–1.285	0.714
T stage
T3 or T4 (n=188)
T1 or T2 (n=336)	3.115	2.302–4.217	0.000		1.580	1.101–2.266	0.013
N stage
N1 (n=15)
N0 or NX (n=509)	3.914	2.119–7.228	0.000		2.081	1.094–3.961	0.026
M stage
M1 (n=78)
M0 or MX (n=446)	4.300	3.153–5.863	0.000		2.693	1.880–3.860	0.000
G grade
G3 or G4 (n=280)
G1 or G2 or GX (n=244)	2.610	1.863–3.657	0.000		1.700	1.181–2.447	0.004
USP2
High (n=262)
Low (n=262)	0.572	0.419–0.781	0.000		0.618	0.449–0.850	0.003

^aHazard ratio, estimated from Cox proportional hazard regression model. ^bConfidence interval of the estimated HR. ^cMultivariate models were adjusted for T, N, M, G classification, age, gender and USP2 mRNA level.