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. 2020 Mar;8(6):310. doi: 10.21037/atm.2020.02.129

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Chronic ethanol exposure induced FGF21 resistance. Quantitative RT-PCR determined relative β-klotho (A) and FGF receptor (FGFR) (B) mRNA levels in islets isolated from mice after 1–3 weeks of being gavaged with or without ethanol. (C) Increased levels of serum FGF21 levels in terminal bleed blood, determined by ELISAs, after 3 weeks of ethanol exposure. (D) Western blot, with β-actin densitometry loading control, demonstrating ethanol exposure-induced elevation of FGF21. Data are means ± SEs; *P<0.05, **P<0.01, ***P<0.001 vs. time-matched saline gavaged group (N=5 per treatment-time group).