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Morphine induces Bcl-2, cyclind1, and VEGF mRNA expression downregulation and upregulation of Bax in tumors of nude mice. Data are expressed as the mean ± SEM. *, P<0.05 vs. group C, NS, N and MN. Group C, control; Group NS, 1.5 mL/kg NS; Group M1, 5 mg/kg morphine; Group M2, 10 mg/kg morphine; Group M3, 20 mg/kg morphine; Group M4, 40 mg/kg morphine; Group N, 1 mg/kg naloxone; Group MN, 20 mg/kg morphine and 1 mg/kg naloxone.
